Ion channels as potential redox sensors in lysosomes
نویسندگان
چکیده
منابع مشابه
Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling.
SIGNIFICANCE Mitochondrial ion channels/transporters and the electron transport chain (ETC) serve as key sensors and regulators for cellular redox signaling, the production of reactive oxygen species (ROS) and nitrogen species (RNS) in mitochondria, and balancing cell survival and death. Although the functional and pharmacological characteristics of mitochondrial ion transport mechanisms have b...
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Hypoxia inhibits voltage-gated K channels in pulmonary artery smooth muscle (PASM). This is thought to contribute to hypoxic pulmonary vasoconstriction by promoting membrane depolarization, Ca(2+) influx, and contraction. Several of the K-channel subtypes identified in pulmonary artery have been implicated in the response to hypoxia, but contradictory evidence clouds the identity of the oxygen-...
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Cells are demarcated by the cell membrane. The cell membrane is a lipid bilayer in which various protein molecules are embedded (see Figure 1). In all animal cells, there is a large difference in ionic concentration between inside and outside the cell (Table 1). Na concentration is higher outside the cell and the K concentration is higher inside the cell. Intracellular Ca concentration is kept ...
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SIGNIFICANCE Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only known to exert toxic effects on organisms, but are also emerging as molecules that mediate cell signaling responses. However, the mechanisms underlying this cellular redox signaling by reactive species remains largely uncharacter...
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Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...
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ژورنال
عنوان ژورنال: Channels
سال: 2019
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2019.1684428